Drug half-life

The time required for the concentration of a drug in the plasma to reduce by 50% through metabolism and excretion. A fundamental metric in pharmacokinetics.

Key Parameters

• Governs dosing interval and the time required to reach steady state.
• Dependent on clearance and volume of distribution.

Observations

• 2026 04 14 Malaria vaccination via mosquitos: In malaria vaccination models using mosquitoes, animals can achieve lifelong protection from reinfection despite the drug having a very short half-life.

2026 04 14 Malaria vaccination via mosquitos

Source Notes

• 2026-04-14: # Malaria vaccination via mosquitos --- --- wow - despite a really short half life of the drug the animals are protected for life from reinfection (Malaria vaccination via mosquitos)